https://astlabweizmann.com

Tslil Ast Lab | Iron-Sulfur ClustersThe Ast lab at the Biomolecular Sciences department of Weizmann Institute studies the role of iron-sulfur clusters in human health and disease. Blending cutting edge genetic and high content approaches with cell biology and biochemistry, we aim to shed new light on this essential pathway.Tslil Ast Lab | Iron-Sulfur Clusters top of pageDepartment of Biomolecular SciencesHOMERESEARCHJOIN USPUBLICATIONSPEOPLEGALLERYMoreUse tab to navigate through the menu items.Ast LabCell biology of iron-sulfur clustersABOUTAbout us Mitochondria are essential for the function of the eukaryotic cell- why? Over the past two decades it has become apparent that a core and ubiquitous function of mitochondria is iron-sulfur (Fe-S) cluster biosynthesis. ​Fe-S clusters are redox cofactors that are vital for multiple processes in and beyond mitochondria; DNA replication and repair, protein translation and oxidative phosphorylation.  Our lab studies how Fe-S cluster synthesis is integrated into human cell biology in health and disease. We couple cutting edge genetic and high content tools with cell biology and biochemistry approaches to shed new light on this essential pathway. OUR BIG QUESTIONS Which human processes and pathways rely on Fe-S clusters? How is Fe-S cluster biosynthesis regulated? How are human cells rewired once this pathway has broken down in disease? Learn more Join UsContact usTslil Ast, Ph.D., Principal Investigator Biomolecular Sciences Dept., Benoziyo Building, Rm 479 Weizmann Institute of Science tslil.ast@weizmann.ac.il +972-8-9346226bottom of pageenenhttps://astlabweizmann.com

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