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Collaborative Science Conference (CoSci)Register online for Collaborative Science Conference here.Collaborative Science Conference (CoSci) Help Links ?Resend ConfirmationTransfer My RegistrationLoginContactLodging and Hotel☰Join Mailing ListCommunity BoardFAQMarch 13-15, 2026Las Vegas, NevadaStudent Union & Event Services Ballroom - University of Nevada Las VegasAbout This EventThe Collaborative Science Conference, known as 'CoSci,' is a charity fundraising event organized to benefit the Citizen Science Foundation in the form of a scientific conference. It brings together formal and citizen scientists, alongside professionals from various fields, to foster discussion and innovation in health and nutrition. The conference features presentations, panel discussions, and debates representing a wide range of perspectives.Location InformationLocation NameStudent Union & Event Services Ballroom - University of Nevada Las VegasAddressStudent Union & Event Services, Las Vegas, NV, 89154 USDirectionsGoogle, Bing, MapQuestCountdown:NaN days, NaN hours, NaN minutes, NaN secondsSchedule (subject to change)Bonus Evening - Thursday, March 12, 20266:00 PMLive Filming of The Feldman Protocol Podcast with Guest Dr. Ken Berry (add-on ticket required)Join us for a live filming of The Feldman Protocol podcast with guest Dr. Ken Berry. Get up close, ask your questions, and dive deeper into the conversations that matter most.Limited tickets available for this exclusive, separate event. Don't miss out!Location: Philip J Cohen Theatre - Student Union & Event Services (1st floor) at University of Nevada Las VegasDoors Open: 5:45pmDay 1 - Friday, March 13, 202610:00 AMCheck-In / ExpoPick up your conference badge and swag, visit our sponsor booths, and get to know your fellow attendees.10:45 AMSeating OpensSeating opens for the start of CoSci Day 111:00 AMWelcome - Dave FeldmanWelcome11:15 AMWomen's Health PanelWomen’s health is too often underrepresented in conversations about metabolism, nutrition, and chronic disease. This special panel brings together three leading voices—Dr. Annette Bosworth, Siobhan Huggins, and Dr. Lily Johnston—to highlight critical topics in women’s metabolic health that deserve far more attention.Each panelist will share insights on an overlooked aspect of women’s health, drawing from their clinical experience, research, and advocacy work. From hormonal influences on metabolism to the unique challenges women face in nutrition and disease prevention, this discussion aims to shed light on issues that impact millions but are rarely discussed openly.The session will conclude with an interactive audience Q&A, giving attendees the opportunity to engage directly with the panelists and explore questions about women’s health, metabolism, and practical strategies for improving long-term wellbeing.12:45 PMBreak / ExpoVisit our sponsor booths, and get to know your fellow attendees.1:15 PMDr. Lily Johnston: The Proof Is In the Plaque: Rethinking Cardiovascular RiskCardiovascular prevention remains heavily reliant on population-based estimates (biomarkers and risk scores) that do not directly quantify atherosclerotic burden. In this talk I present an imaging-centered framework for individualized risk assessment: while demographics and biomarkers lead to sophisticated probabilistic guessing, while plaque imaging provides direct, concrete disease detection. We compare the indications, strengths, and limitations of CAC, CCTA, and CIMT/plaque imaging, with emphasis on clinical trade-offs, patient selection, and longitudinal use. Case-based discussion illustrates how integrating imaging with metabolic and other biomarker data improves risk stratification and therapeutic precision. Moreover, atherosclerosis is biologically dynamic: with targeted lifestyle and pharmacologic intervention, plaque progression can be stabilized and, in selected contexts, partially regressed. Attendees will leave with a practical model for moving from population-level prediction to patient-specific detection, treatment, and tracking.1:45 PMTerrance Boult: Calculator Confusion: Navigating Risk Calculator Selection in the Ketogenic EraCardiovascular risk calculators produce wildly divergent predictions for ketogenic dieters, with the same patient showing 5% to 15% ten-year risk depending on calculator choice. This presentation examines real data from one individual in two distinct metabolic states: modest-carb (120g/day) with statins versus strict ketogenic without statins. Through analysis of three calculator generations—legacy models (MESA) developed pre-statin era, contemporary tools (AstroCharm) incorporating inflammatory markers, and newer frameworks (PREVENT) emphasizing social determinants—attendees will discover why these and others each tells a different story about the same person. The presentation reveals how HDL improvements on keto (40→59 mg/dL) register differently across models, why the trade-off between statin therapy and ketogenic diet creates conflicting risk narratives, and which biomarkers each calculator sees, ignores, or weighs differently. Particularly striking is how inflammation markers (hsCRP) dramatically alter predictions in some models while remaining invisible in others, and how the impact of coronary calcium scoring varies depending on other model parameters. Critically, all calculators carry hidden dietary assumptions, having been trained exclusively on high-carbohydrate populations, leaving them unable to accurately assess ketogenic physiology. Attendees will gain a practical understanding of calculator nuances—not to identify the "right" one, but to comprehend what each reveals and conceals about cardiovascular risk in ketogenic versus modest-carb metabolic states, enabling more informed healthcare discussions.2:00 PMBen Bocchicchio: Are Lean Mass Hyper Responders Born Or Made?LMHR (Lean Mass Hyper-Responders) have been described in the literature proposed as a constellation of behavioral and metabolic indices. This presentation provides some simple observations regarding LMHR status and its correlation to atherosclerotic risk. The question arises as to the potential attainment of said metabolic status and it’s consequences.2:30 PMDavid Crutchfield: Troubleshooting Inflammation: When Keto is not EnoughThe ketogenic diet (KD) is generally associated with anti-inflammatory effects, primarily through the production of beta-hydroxybutyrate (BHB) and reductions in insulin and visceral adipose tissue. This session will focus on what happens with persistent or chronic inflammation even in the face of ketogenic metabolic therapy (KMT) as it may indicate issues in the diet's execution or other underlying factors.2:45 PMBreak / ExpoVisit our sponsor booths, and get to know your fellow attendees.3:15 PMAmber O'Hearn - Ketosis mimetics: a crash tourThe state of ketosis we get from a ketogenic diet is not merely a change from burning primarily glucose to burning primarily fat; it is a coordinated set of biochemical pathways working together differently. It is hard to attribute the therapeutic benefits we derive from ketogenic diets to any one aspect of this whole, so when we look to interventions that aim to mimic these benefits, we need to understand both where they overlap with nutritional ketosis and where critical differences may lie. Using an energostatic framework, in which energy production is treated as the key regulated variable, we examine how different ketosis mimetics, such as fasting, MCTs, exogenous ketones, mitochondrial uncouplers, and the “triple-agonist” peptide retatrutide, map onto the ketogenic metabolic state. Rather than asking whether a mimetic “works,” we ask which parts of the ketogenic pathway it replicates, and how that may affect the system as a whole. This perspective helps explain why no single intervention reproduces ketosis in full, why mixed interventions can generate conflicting responses, and why mimetics would be expected to behave differently when layered onto low-carbohydrate baselines as adjuncts rather than pasted onto a conflicting system. Finally, we consider how different components of the energy transport system from lipolysis through the electron transport chain, and the transduction of satiation signals to the brain can each act as bottlenecks, such that mimetics affecting one component but not others may be more or less appropriate interventions for individuals.3:45 PMDarius Sharpe: Postprandial Hyperglycemia: The Root of it AllIn the metabolic health and low-carb community, we focus a lot on insulin and hyperinsulinemia. Often complaining that conventional medicine has too much of a glucose-centric view. Things like A1c and fasting glucose levels remain normal for years while insulin is high, but never caught. However, we fail to acknowledge that high insulin cannot exist without high glucose. Otherwise a lot more people would be hypoglycemic! The piece that has been largely missing in research, medicine, and nutrition is how post-meal glucose excursions are the singular initiating factor in hyperinsulinemia, oxidative stress, and a host of other effects that produce a transient atherogenic milieu. Unfortunately, in our modern world, those excursions, although transient, occur frequently, causing cumulative damage over the long term in many people. Thanks to continuous glucose monitoring technology, we are starting to see how postprandial hyperglycemia is common even in people with no signs of metabolic dysfunction and eating what most people would consider a healthy diet.4:15 PMSiouxie Boshoff: Ancestral Ideals, Modern Reality: Building Metabolic Armor in a Synthetic WorldWe know what health looked like for our ancestors—clean food, natural light, movement, and balance with the Earth. But can any of that still exist in 2026? Between industrialized food systems, synthetic ingredients, environmental toxins, and a pace of life that disconnects us from nature, ancestral living has become nearly impossible. In this talk, I explore the historical turning points that broke our biological connection to food and environment—from the birth of hydrogenated oils and petrochemical preservatives to the contamination of our soil and water. Yet amidst the chaos, there’s a path forward. By focusing on metabolic resilience—stabilizing blood sugar, restoring insulin sensitivity, and supporting detoxification—we can build internal armor against our modern world. Using continuous glucose monitoring, ketogenic nutrition, and real biomarker data (zero CAC, strong HDL, low CRP), I’ll share how I rebuilt my metabolism despite chronic illness and decades of inflammation. This isn’t nostalgia for the past—it’s a roadmap for the future: understanding how our environment shapes biology, and how modern humans can use ancestral principles, metabolic science, and self-tracking to restore balance, vitality, and true health—even in an artificial world.4:30 PMAmy Berger: Priming Your Head for Success: You Know What to Do ... So Why Aren't You Doing It?No one needs another food list or set of rules. You've been around the diet block a few times. This isn't your first, second, or thirteenth rodeo. Many different approaches can work for improving your health or losing weight, but they all have a shortcoming in common if they only tell you what to do and not how to do it. How to do it when you're tired, stressed out, doubting yourself, or don't believe in yourself. Nutritionist Amy Berger will walk you through concrete mindset shifts to help you break old, unhelpful patterns and go from wishing and hoping to taking action.5:00 PMEnd of Day 1See you tomorrow for Day 2!5:15 PMVenue ClosedExpo & Venue will close at this time5:30 PMVIP Dinner (for Emerald & Diamond tickets only)Fogo de Chão360 E Flamingo Rd, Las Vegas, NV 89169Day 2 - Saturday, March 14, 20267:30 AMDoors Open / ExpoPick up your conference badge and swag, visit our sponsor booths, and get to know your fellow attendees.8:00 AMBret Scher: Breaking BarriersNow more than ever we need to break barriers that impede medical progress. It is a failure of medical practice to withhold potentially safe and effective nutritional and lifestyle interventions while patients live with unrelenting symptoms, searching for something better. Metabolic Psychiatry is a prime example of this medical failing. Metabolic Mind and The Citizen Science Foundation are examples of positive work in this field, yet barriers remain. How can we work together to change medical practice and provide healing interventions to those who could benefit?8:30 AMNicholas Norwitz: Is Medicine CapturedTBA9:00 AMJenny Mitich: 21 Days on Sardines: Results, Lessons, and the “Why It Worked”In this talk, I’ll make the case for one of the most underrated “high-return” foods in nutrition: sardines—and then I’ll show you exactly what happened when I put that theory to the test with a 21-day sardine fast.I’ll start with a fast, practical introduction to sardines: what they are, why they’re uniquely nutrient-dense, and how their specific “stack” of protein, omega-3 fats, and key micronutrients can influence satiety, inflammation, blood sugar stability, and metabolic signaling. Instead of treating sardines like a gimmick food, I’ll frame them as a tool—simple, portable, and surprisingly powerful in a real-world diet.From there, I’ll share my N=1 data from 21 days of sardines, including before-and-after bloodwork, DEXA changes, continuous glucose monitoring trends, and daily ketone observations. I’ll walk through what moved, what didn’t, and what surprised me—along with the patterns that may explain the results (and the limitations of a single-person experiment). The goal is to translate “I tried it” into measurable outcomes that can spark smarter personal experimentation.Finally, I’ll turn the experiment into a repeatable protocol. I’ll outline how to run a sardine fast safely and effectively, what to eat (and what to avoid), how to structure portions and timing, what side effects or “adaptation” symptoms to anticipate, and how to know if this approach is a fit for you. Attendees will leave with a clear framework for testing sardines as a short-term reset—or a long-term upgrade—using data, not guesswork.9:30 AMBreak / ExpoVisit our sponsor booths, and get to know your fellow attendees.10:00 AMLMHR PanelThe Lean Mass Hyper Responder (LMHR) phenotype has become one of the most talked-about and debated topics in metabolic health and lipid research. Characterized by a unique pattern of elevated LDL cholesterol alongside high HDL and low triglycerides—often seen in metabolically healthy individuals following low-carbohydrate or ketogenic diets—LMHRs challenge traditional assumptions about cardiovascular risk.Join Dr. Nadir Ali, Dr. Nick Norwitz, and Dr. Bret Scher for an in-depth panel discussion exploring the science, clinical implications, and ongoing research surrounding this fascinating metabolic phenotype.Each panelist will share their perspective on LMHRs—from emerging research and clinical observations to what this phenomenon may mean for our understanding of cholesterol, metabolism, and cardiovascular health.The session will conclude with a live audience Q&A, giving attendees the opportunity to ask questions and engage directly with the panelists about one of the most intriguing topics in metabolic science today.12:00 PMLunch BreakEnjoy lunch downstairs in the food court or nearby restaurants and network with fellow attendees.1:30 PMCynthia Thurlow: The Menopause Gut: The Microbiome as a Regulator of Aging in Women1. Understand the bidirectional relationship between perimenopause/menopause-related hormonal changes and the gut microbiome2. Identify gut-driven contributors to persistent perimenopause/menopause symptoms despite standard interventions3. Apply practical, evidence-informed strategies to support gut–hormone health in midlife women, including lifestyle measures and HRT therapies2:00 PMBeth Zupec-Kania: A ketogenic diet therapy plus moderate exercise reversed my menopausal insulin resistanceMenopause represents a complex biological transition that profoundly affects women’s metabolic health, particularly by increasing the risk of insulin resistance. The decline in estrogen during perimenopause and menopause leads to reduced insulin sensitivity, making women more susceptible to impaired glucose regulation. This risk is compounded by factors such as weight gain—especially increased abdominal fat—altered fat distribution, decreased physical activity, sleep disturbances, and heightened stress, all of which can elevate cortisol levels and further exacerbate insulin resistance. Collectively, these changes heighten the likelihood of developing type 2 diabetes and other metabolic disorders.Hormone replacement therapy (HRT) may improve insulin sensitivity in select cases, but its use requires careful, individualized risk-benefit assessment. Early recognition of these metabolic shifts is critical for timely intervention. Lifestyle modifications, including balanced nutrition, regular exercise, stress management, and adequate sleep, are essential strategies to mitigate the adverse metabolic consequences of menopause.My personal narrative illustrates the potential benefits of ketogenic diet therapy. After experiencing the typical symptoms of peri-menopause at age 50, I adopted a ketogenic diet, which resulted in improved sleep, resolution of hot flashes, and normalized glucose and insulin levels. Seventeen years later, I’m enjoying excellent metabolic and cardiovascular health, absence of osteoporosis, and sustained well-being with a moderate exercise routine - all without HRT. This experience underscores the importance of individualized approaches and proactive management to optimize health outcomes during menopause.2:15 PMAdrian Soto-Mota: Cleerly, there's a problem. Why does it matter? Why doesn't it?I'll present and discuss how coronary plaque measurements compare between different CCTA methods in the Keto-CTA cohort and its scientific and clinical implications.2:45 PMBreak / ExpoVisit our sponsor booths, and get to know your fellow attendees.3:15 PMCraig Emmerich: Energy Toxicity: Lipotoxicity and Glucotoxicity, Two Sides of the Same CoinThis presentation examines lipotoxicity and glucotoxicity as two sides of the same metabolic problem: energy toxicity caused by limited storage capacity. When glycogen and adipose tissue reach their storage limits, excess fuel spills into the liver, pancreas, muscle, and bloodstream, driving insulin resistance, elevated triglycerides, and rising fasting insulin—even when blood glucose remains normal. Central to this framework is the concept of the personal fat threshold, which explains why individuals develop metabolic disease at different body weights and why ectopic fat accumulation, not obesity alone, is the true root of insulin resistance.The talk reframes insulin’s role as a fuel-buffering regulator or fuel thermostat rather than merely a storage hormone, highlighting the dominant impact of chronically elevated fasting insulin. Key clinical markers of lipotoxicity are reviewed, along with common misconceptions about insulin, fat intake, and fat loss. The presentation concludes with a mechanism-based overview of strategies to reverse lipotoxicity and glucotoxicity—lowering fasting insulin, restoring healthy fat storage, prioritizing protein and muscle preservation, and adjusting carbohydrate and dietary fat intake based on individual metabolic context.3:45 PMDr. Nadir Ali: Coronary CT angiography (CCTA) – What do the statin regression trials show!Coronary CT angiography (CCTA) is increasingly used to quantify longitudinal change in total plaque volume (TPV), non-calcified plaque volume (NCPV), calcified plaque volume (CPV), and coronary artery calcium (CAC) in response to pharmacotherapy, including statins.However, technical and physiologic variability materially limits the reliability of small serial changes on CCTA and must be explicitly accounted for when trials use plaque change as an endpoint. Key constraints include spatial resolution (≈0.5 mm) and temporal resolution (≈140 ms for many single-source CT systems). Scan–rescan variability can be introduced by vasomotor tone, cardiac output/hemodynamics, patient positioning, and timing of nitroglycerin and contrast, all of which can alter coronary attenuation (Hounsfield units) and shift plaque classification and segmentation. Calcium blooming further alters adjacent voxels and can bias plaque quantification. Finally, post-processing effects (centerline selection, vessel length analyzed, thresholding/segmentation choices, and software/version drift) can change measured plaque volumes even when underlying biology is unchanged.Therefore, trials should pre-specify minimal detectable change (MDC) thresholds at both the individual and group level, and interpret reported plaque changes relative to these MDC boundaries rather than statistical significance alone.When evaluated through this lens, statin “regression” trials often demonstrate statistically significant increases in group CAC and CPV, and in some datasets increases in group TPV, while reported changes in NCPV frequently do not exceed plausible measurement noise and may fail to cross a group MDC threshold required to infer a true change. The dominant measurable changes are increases in CAC and CPV (often TPV), supporting an interpretation of plaque progression on CCTA, with potential implications for adverse outcomes.4:15 PMDr. Ken Berry: Title TBATBA4:45 PMEnd of Day 2Thanks for attending! See you for Day 3!5:00 PMVenue ClosedExpo & Venue will close at this time6:00 PMSpecial Screening of The Cholesterol Code Documentary (add-on ticket required)Location: The Beverly Theater - 515 S 6th St, Las VegasDoors open at 5:00pm.Film will start promptly at 6:00pm with a panel discussion immediately following. Keto friendly food and wine will be served. Cocktail attire recommended.Limited tickets available for this exclusive, separate event. Don't miss out!Day 3 - Sunday, March 15, 20267:30 AMDoors Open / ExpoPick up your conference badge and swag, visit our sponsor booths, and get to know your fellow attendees.8:00 AMDr. Eric Westman: A review of the clinical research on keto diets: Where do we go from here?While best known as a popular diet for weight loss, the keto diet has decades of research exploring its potential to treat or prevent many other medical conditions. This lecture will summarize clinical research on low carbohydrate and ketogenic diets through an evidence-based medicine lens to provide a roadmap for future clinical research and clinical care.8:30 AMMatt Baszucki: Mental Illness & Metabolic Therapies: My StoryFrom 2016-2018, I was hospitalized four times for manic psychosis, and I received a bipolar disorder diagnosis. I tried dozens of medications and doctors. I stayed at treatment centers all over the country. But nothing worked. My condition deteriorated, and towards the end of that year, I was homeless and psychotic on the streets of Southern California.A year later, our family discovered ketogenic therapies. This is the story of how a simple diet helped me recover my life. And, as our family now contributes to research into metabolic psychiatry, it might have started a movement as well.9:00 AMDominic D'Agostino: Brain Energy and Brain Injury: Considerations for Older AdultsTraumatic brain injury (TBI) is often associated with young athletes or military service, yet it is most common—and most dangerous—in older adults. After age 65, and especially after 80, even minor head impacts can lead to serious and lasting brain injury. As a result, what might be a brief setback at midlife can become a life-altering event later in life. This evolving understanding reframes brain injury as a problem of energy failure and reduced resilience, rather than impact alone. The lecture will highlight evidence-based strategies to protect brain health and improve recovery, including fall prevention, strength and balance training, targeted exercise, metabolic and nutritional support, and thoughtful medication management. By supporting brain energy systems and resilience, we can reduce injury risk, preserve cognitive function, and improve outcomes for aging individuals.9:30 AMBreak / ExpoVisit our sponsor booths, and get to know your fellow attendees.10:00 AMThe Cholesterol Code Documentary PanelComing off of Saturday evening's screening of The Cholesterol Code documentary at The Beverly Theatre, this special panel discussion features individuals whose stories and perspectives helped shape the film.Moderated by the film’s director, Jennifer Isenhart, this conversation will feature Matt Baszucki, Robyn Dobbins, and Eric Rodgers, who appear in the documentary and bring powerful personal experiences to the ongoing discussion around cholesterol, metabolic health, and emerging science.Jennifer will guide the discussion with questions that explore both what audiences saw in the film and stories or insights that may not have made it to the final cut. The panel will dive deeper into the lived experiences behind the research and the motivations that drove the creation of the documentary.Whether you attended the screening the night before or are encountering these ideas for the first time, the conversation will provide meaningful context and personal perspectives on the themes explored in the film.The session will conclude with an audience Q&A, giving attendees the opportunity to engage directly with the panelists and continue the conversation.11:30 AMLunch BreakEnjoy lunch downstairs in the food court or nearby restaurants and network with fellow attendees.1:00 PMDr. Annette Bosworth: Sequenced Metabolic Repair: Overcoming Refractory Insulin Resistance and GLP-1 Insensitivity in a Complex Comorbidity PatientBackground: Standard management of Type 2 Diabetes (T2D) often relies on pharmacological escalation or caloric restriction. However, patients with a history of severe chronic metabolic stress often present with ""metabolic blockage,"" a state of profound mitochondrial dysfunction where traditional interventions fail. This case explores a sequenced therapeutic protocol designed to restore metabolic flexibility in a refractory patient.Case Presentation: A 65-year-old male with a history of T2D, colorectal cancer (status post-resection/chemo), obesity, and bilateral lower extremity fractures presented with uncontrolled metabolic syndrome. Baseline assessments revealed an HbA1c of 10.9%, Triglycerides of 547 mg/dL, and significant pitting edema. The patient was refractory to standard rigorous interventions: a documented 21-day water fast failed to induce therapeutic ketosis (Glucose 108 mg/dL, Ketones 0.7 mmol/L), and a two-year course of maximal-dose tirzepatide (15 mg) yielded no weight loss or symptom relief.Intervention: A ""Repair Before Push"" protocol was implemented, prioritizing mitochondrial function over caloric deficit. Phase 1 involved specific high-fat/protein nutritional ketosis (sardine protocol) to trigger mitophagy without starvation stress. Phase 2 reintroduced tirzepatide at an off-label micro-dose of ~0.6 mg (4% of the standard dose) only after ketone production was naturally restored.Outcomes: Over a 90-day period, the patient achieved significant metabolic reversal. HbA1c declined from 10.9% to 6.0%, and weight decreased by 44 lbs. Clinical signs of edema resolved, and the patient demonstrated restored metabolic flexibility, with fasting glucose consistently <100 mg/dL and a Glucose-Ketone Index shifting from >150 (crisis) to <20 (optimal).Conclusion: This case suggests that in patients with complex mitochondrial damage, restoring cellular chemistry via specific nutrition is a necessary precursor to effective fasting or pharmacotherapy. It further highlights the potential for micro-dosing GLP-1 agonists once metabolic sensitivity is restored.1:30 PMEmily Harari: How to actually personalize medicine: Microsampling as the avenue to personal baseliningAs long as bloodwork reference intervals rely on population averages, we’ll never achieve the level of personalization we’re aiming for in precision medicine. This barrier is a symptom of our healthcare system’s inability to scale, namely in the area of sample collection. But what if collecting blood was as simple as a painless test kit that patients mail from home? Microsampling technologies introduce the promise of longitudinal sampling and, therefore, highly personalized clinical care. However, with at-home test kits already flooding the market, we need to parse apart signal from noise. This presentation introduces microsampling as the scalable approach to specimen curation that will enable us to bring precision medicine to more people, regardless of their geography. We’ll address the scientific questions, like “Which blood tests have been validated on microsamples?” We’ll interrogate the practical questions, like “How do patients and physicians actually use these technologies?” And finally, we’ll discuss, “Where can microsampling advance the field of metabolic research and treatment?” The presentation will incorporate existing published data, the speaker’s experiences running decentralized research studies for biotech startups, and– in true citizen science fashion– her own anecdotal data. While technical and solutions-oriented, this presentation will incorporate stories from the biotech startup trenches, highlighting the rapid, boot-strapped studies that microsampling enables and the stories of patient empowerment that emerge, as a result.1:45 PMStephen Hussey: Atherosclerosis: Are We Asking the Wrong Question?Asking if cholesterol, LDL, ApoB, Lp(a), or any form of lipoprotein causes atherosclerotic heart disease narrows the focus to the lipids in the blood. However, the environment where plaque occurs is much more complex than just lipids. After decades of asking questions that narrow the focus, the answer remains somewhat elusive. It's time to ask different questions.2:15 PMJenna Ericson: Reactive Oxygen Species and Physiological Insulin ResistanceProtons and electrons derived from NADH and FADH2 are the precursors to ATP production in mitochondria. Complex 1 is where NADH is oxidized to send electrons into the electron transport chain, and Complex 2 is where FADH2 is oxidized to do the same. These electrons that enter through Complex 1 and 2 meet up at the COQ10 coupling where ubiquinone is reduced. Different energy carrying molecules such as fatty acids and glucose produce different amounts of NADH and FADH2. If the amount of FADH2 derived from a molecule is high enough, ubiquinone is fully reduced with electrons to spare. These extra electrons bounce back out through complex 1 where they combine with oxygen to create a superoxide, a type of reactive oxygen species. These superoxides leave the mitochondria where they are converted to hydrogen peroxide. At higher levels, hydrogen peroxide inhibits activation of the insulin receptor, thereby causing physiological insulin resistance. The energy carrying molecules that create the most reactive oxygen species are long chain saturated fats. Therefore, long chain saturated fatty acids are the true cause of physiological insulin resistance because they carry the most energy, have the most hydrogen bonds, and produce the highest ratio of FADH2 to NADH. Glucose creates the least FADH2, meaning the least reactive oxygen species. Polyunsaturated fats create less FADH2 than other fats during beta oxidation because additional enzymes are needed due to the double bonds.2:30 PMBreak / ExpoVisit our sponsor booths, and get to know your fellow attendees.3:00 PMLouis Burns: All Models Are Wrong: Reconciling Carbs vs CaloriesWhy can't nutritionists, doctors, and scientists agree on whether calories or carbs matter more for weight loss? Both sides have evidence and success stories, yet they talk past each other as if they're speaking different languages. I experienced this firsthand: I briefly lost weight with low-fat calorie restriction, but I quickly regained it and developed IBS symptoms. Low-carb healed my gut, but I didn't lose weight. Only when I combined both approaches did everything click, and that's when I realized the real problem. These aren't mutually exclusive models. They're explaining entirely different experiences. Philosopher Thomas Kuhn called this "incommensurability"—when people use the same words but mean completely different phenomena. Economists and psychologists used to talk past each other about "decision making" until behavioral economics showed they were both right about various aspects of human behavior. Energy balance explains body composition better. Low or zero-carb explains metabolic health and how chronically elevated glucose contributes to diabetes, heart disease, and cancer. This talk shows how recognizing what each model explains better gives us a practical framework for making sense of contradictory nutrition advice.3:15 PMSiobhan Huggins: Metabolic Health for Cancer Treatment Related Lymphedema Prevention: A HypothesisLymphedema is a long-term and often permanent side effect of cancer treatment. It causes ongoing swelling in the affected area of the body, along with tissue hardening (fibrosis) and excess fat buildup. Currently, most attention is focused on how to manage lymphedema after its already developed, but avenues to explore cancer treatment related lymphedema prevention are equally important. While several risk factors are known, it’s still difficult to predict which individuals will develop lymphedema. One risk factor of importance is poor metabolic health and pathological insulin resistance. In this talk, we will explore the hypothesis that introduction of metabolic therapies, like ketogenic diets, prior to cancer treatment may be a promising approach in individuals vulnerable to developing lymphedema.3:45 PMShawn Baker: Back to my rootsTBA4:15 PMDave Feldman: 100 HeartsTBA4:45 PMThank You / Raffle / ClosingLet's give away some raffle prizes!5:00 PMEnd of Day 3Thank you for attending CoSci! Safe journey home.5:15 PMVenue ClosedExpo & Venue will close at this time5:15 PMFarewell Reception (Gold, Emerald, & Diamond tickets only)Ballroom LobbySpecial Events (Add-On Ticket Required)Speakers (subject to change)Dave Feldman Host & Featured SpeakerDave Feldman is the originator of the Lipid Energy Model and the Lean Mass Hyper-Responder (LMHR) phenotype, reshaping how we understand cholesterol and metabolism. As founder of the Citizen Science Foundation, he leads groundbreaking research into lipid metabolism, cardiovascular health, and metabolic responses to ketogenic diets. Dave’s work includes spearheading the Keto-CTA study, which investigates how diet influences plaque progression and regression using advanced imaging. A passionate advocate for open science, he engages with researchers, clinicians, and the public to challenge assumptions, foster transparency, and drive innovative, data-driven insights into cardiovascular risk and human metabolism.Dr. Nadir Ali, MD Featured SpeakerDr. Nadir Ali is a practicing Interventional Cardiologist in the Clear Lake and Houston community area for over 30 years.He has several years of experience in the Low Carbohydrate High Fat (LCHF) diet in the treatment of metabolic disease, diabetes, heart disease and to improve the quality of cholesterol. He and his team give free diet seminars for his patients once a month on the last Wednesday of every month at 6 pm at the Searcy Auditorium in the Clear Lake Heart and Vascular Institute. This class has had more than 100 attendees for each session consistently for the last 4+ years.Shawn Baker, MD Featured SpeakerFounder Revero Health, Physician, Father, Author, Athlete, Steak enjoyerMatt Baszucki Featured SpeakerMatt Baszucki is a patient advocate and co-host of the Bipolarcast podcast, along with Iain Campbell. Matt struggled with type 1 bipolar disorder for five years. He was hospitalized four times for manic psychosis, saw dozens of psychiatrists and specialists, and attended multiple treatment centers. In 2021, Matt used the ketogenic diet to treat and cure his disorder. Now, on their podcast, he and Iain interview other patients who have used metabolic therapies to treat their illnesses. They also discuss general metabolic interventions, including physical exercise, circadian rhythm management, and meditation. In his free time, you can find him digging into biographies, playing chess, practicing piano, or pushing weight at the gym.Amy Berger Featured SpeakerAmy Berger, MS, CNS, is a U.S. Air Force veteran and Certified Nutrition Specialist who helps people do “Keto Without the Crazy.”™ She writes about a wide range of health and nutrition-related topics, such as weight loss, diabetes, Alzheimer's disease, thyroid function, and more. She has presented internationally on these issues and is the author of The Alzheimer's Antidote, The Stall Slayer, and co-author of End Your Carb Confusion (written with Eric Westman, MD). She is the Lead Nutritionist for Adapt Your Life Academy, where she creates course content and coaches people through implementing low-carb keto diets safely and effectively. She contributed to the American Nutrition Association’s Ketogenic Nutrition Training Program and served on the BCNS exam review committee, which writes the credentialing board exam for Certified Nutrition Specialists.Dr. Ken Berry Featured SpeakerDr. Ken D. Berry is a board-certified family physician, best-selling author of Lies My Doctor Told Me, and co-author of the updated & expanded Second Edition of Common Sense Labs. He educates millions through his 3M+ subscriber YouTube channel and champions a nutrient-dense, low-carb Proper Human Diet. He lives in Holladay, Tennessee, with his wife Neisha and their children.Vincent (Ben) Bocchicchio, PhD Featured SpeakerDr. Ben Bocchicchio has been a pioneering force in health and wellness for nearly 50 years, focusing on effective, science-based interventions for degenerative diseases. His approach emphasizes the need to shift from illness to wellness through safe, evidence-backed behavioral strategies.In 1974, Dr. Ben introduced slow resistance training to promote safe, high-intensity exercise for all populations. He was the first to incorporate resistance training into Phase II cardiac rehabilitation in 1982, a practice now standard. In the mid-1980s, he also pioneered high-intensity training for endurance athletes and later for weight loss, including the OptiFast protocol used by leading bariatric physicians.Dr. Ben has critiqued the reliance on pharmaceuticals in treating chronic diseases, such as diabetes, heart disease, and obesity, pointing to the lack of solid scientific backing for conventional medical practices. His work underscores the link between lifestyle choices—particularly diet and exercise—and the rise of degenerative diseases.He has authored over 200 articles and reports, and his acclaimed book, 15 Minutes to Fitness, has contributed to his global impact. Dr. Ben's SMaRT DVDs have sold more than 300,000 copies in 31 countries. He continues to serve as an investigator and consultant for Johns Hopkins School of Medicine, ASU, and other health institutions, offering practical, universally applicable solutions for improving public health.Siouxie Boshoff Citizen Science SpeakerSiouxie Boshoff is a founder, ingredient investigator, and better-food advocate who turned a personal health journey into a practical approach for thriving in a highly artificial modern world. After years of chronic inflammation and metabolic frustration, she began using wearables—especially glucose and ketone tracking—to test food and lifestyle variables with the rigor of an at-home lab. Her work explores the gap between ancestral health ideals and “Life on Earth circa 2026,” including how ingredient sourcing, hidden carriers, and ultra-processed convenience foods can quietly undermine metabolism—even when labels look clean. Siouxie is known for translating complex metabolic science into clear, usable strategies, while calling out the difference between “clean label” marketing and truly clean ingredients. She is the founder of SWITCH®, a brand built on ingredient integrity and real-world metabolic testing to reinvent nostalgic sweets without the usual compromises.Dr. Annette Bosworth Featured SpeakerAnnette Bosworth, M.D., (Dr. Boz), is an internal medicine physician, and an authority on optimizing brain health. Throughout her medical training and career she has taught her patients through storytelling and practical application. Author of the bestseller, ANYWAY YOU CAN, Dr. Boz, has helped patients overcome long-term chronic conditions such as obesity, depression, autoimmune problems, & addiction. Being born into a farming family in rural South Dakota, she witnessed first-hand the value and importance of individual contribution to strengthening a community. She has been featured on CNN, Time, US News & World Report, Fox News, & more.Terrance Boult Citizen Science SpeakerT. Boult, Ph.D., Univ. of Colorado Distinguished Professor Emeritus, is an internationally recognized researcher in Machine learning and Computer Vision and an IEEE Fellow with over 21000 citations. He went keto in 2023 to improve his health and began exploring related nutritional and medical science papers.Louis Burns Citizen Science SpeakerLouis Burns holds an interdisciplinary PhD and founded Metabolic Body Composition, where he coaches health-conscious individuals using evidence-based nutrition strategies. His academic background in complex systems analysis led him to question why nutrition experts can't agree on basic weight-loss principles.With a lifelong interest in health and nutrition, he spent years trying different approaches. After developing IBS from conventional calorie restriction, he achieved sustainable transformation by recognizing that calorie-focused and metabolic-focused approaches explain various phenomena. He lost 35 pounds, reached 7% body fat in his late 40s, discovered he was a lean mass hyper-responder, and went from zero to 42 miles in 2 days of mountain hiking with minimal food.An Airborne Army medic who deployed to Afghanistan, Louis bridges academic rigor with practical application. His forthcoming book, “Metabolic Body Composition”, presents this integrated framework. He continues to read a book a week as he has for the past 29 years.David Crutchfield Citizen Science SpeakerDr Crutchfield is a Board Certified Emergency Physician with over thirty years of experience. Through his own journey he discovered the power of LCHF diets and metabolic interventions such as the power of exercise in mitigating and reversing chronic disease.Dominic D'Agostino, PhD Featured SpeakerDr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). In addition to his teaching responsibilities, his laboratory develops and tests nutritional strategies and metabolic-based therapies for neurological disorders, cancer and metabolic optimization. He is conducting basic science research and human clinical trials. He has a personal interest in environmental medicine and methods to enhance safety and physiological resilience of military personnel in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and nonprofit foundations.Craig Emmerich Featured SpeakerCraig Emmerich graduated in Electrical Engineering who has spent the last 16 plus years researching nutrition and working with thousands of clients along side his wife Maria Emmerich. He is an international best selling author of the “Keto: The Complete Guide” and “The Carnivore Cookbook” and had a part in writing over 25 books. He uses his knowledge of how our bodies work to help clients heal and lose weight leveraging their biology to make it easy. Craig has helped hundreds of thousands of people regain their health and vitality with a strong focus on the science of human nutrition.Jenna Ericson Citizen Science SpeakerJenna Ericson is a patent illustrator with interests in metabolic function, nutrition and the ketogenic diet.Emily Harari Citizen Science SpeakerEmily started out in the lab, where she studied molecular biology at UC Berkeley. Soon after, she worked in the informatics department at Genentech and built multiple biotech startups, helping them scale their clinical operations. As a result, her expertise is in microsampling, at-home test kits, and point of care testing. She has served on the advisory board of the Patient Centric Sampling Interest Group (PCSIG) for the past 2.5 years, where she has grown the international community of scientific founders and life science executives to over 700 members globally. In 2025, she joined Metabolic Collective, where she's building grassroots communities in metabolic psychiatry and neurology. A passionate science communicator, Emily blogs on her channel, The Patient Scientist, where her audience finds research opportunities and greater transparency in the US healthcare system. Emily finds inspiration from her family's resilience in the face of Alzheimer's disease, her personal triumphs in restoring her metabolic health, and the powerful stories shared with her by patient advocates.Siobhan Huggins Featured SpeakerSiobhan Huggins is an independent researcher focused on therapeutic carbohydrate reduction and metabolic health. She also volunteers as the Research Specialist for Lipedema Simplified, a patient advocacy group based out of Boston, MA. After her lipedema diagnosis in 2021, Siobhan expanded her interest to lipedema and related topics like the lymphatic system. After partnering with others interested in the topic, this resulted in a paper exploring the possible utility of therapeutic carbohydrate reduction for cancer treatment-related lymphedema prevention.Dr. Stephen Hussey Featured SpeakerDr. Stephen Hussey is a Chiropractor and Functional Medicine practitioner. His story of personally healing heart disease using light and environmental health strategies has become an inspiration to many and a calling for change in healthcare. In addition to Chiropractic clinical practice, Dr. Hussey is a health consultant, speaker, and the author of three books on health: The Health Evolution, Understanding the Heart, and Pain Sense. Dr. Hussey guides clients from around the world back to health by using the latest research and health attaining strategies.Dr. Lily Johnston Featured SpeakerDr. Lily Johnston is a double board-certified vascular and general surgeon with advanced training in public health. She earned her medical degree from the University of California, San Diego, her Master of Public Health from Johns Hopkins, and completed her general surgery residency at the University of Virginia followed by a vascular surgery fellowship at the Mayo Clinic.Her surgical practice focuses on treating the end stages of atherosclerosis—limb- and life-threatening expressions of cardiovascular disease that expose the downstream cost of metabolic dysfunction. As founder of CorSight Health, Dr. Johnston leads a preventive cardiometabolic clinic dedicated to early detection and reversal of disease through advanced imaging, metabolic assessment, and lifestyle-first interventions.She is an active author and national speaker, with over 25 peer-reviewed publications. Her current focus explores both the science and the culture of medicine—how clinicians’ environments, incentives, and disconnection shape the care they deliver. Her mission is to restore medicine’s roots in meaning, connection, and prevention.Dr. Johnston’s work bridges disciplines—cardiology, endocrinology, obesity medicine, women’s health—to advance preventive cardiometabolic care and reimagine how medicine addresses chronic disease.Jenny Mitich Featured SpeakerAuthor and Carnivore Educator Jenny Mitich used the Carnivore Diet to lose over 50 pounds and overcome severe anxiety and depression. Today, she shares what she’s learned to help thousands of people transition to a meat-based lifestyle and take charge of their metabolic health.A long-term carnivore and full-time content creator, Jenny is known for her practical, no-fluff approach and her belief that people should “know their numbers.” Through educational carnivore content and engaging N=1 experiments, she empowers her audience to track key health markers, make informed decisions, and build a sustainable way of eating.Her book, Complete Carnivore, was released in November 2025. Jenny resides in the Chicagoland area with her husband, Goran, and twin sons, Max and Harry. When she’s not creating content, she enjoys reading, traveling the world, and devouring ribeyes.Nick Norwitz, MD PhD Featured SpeakerNick Norwitz MD PhD is a researcher-educator whose mission is to“Make Metabolic Health Mainstream.” He graduated Valedictorian from Dartmouth College, majoring in Cell Biology and Biochemistry, before completing his PhD in Metabolism at the University of Oxford and his MD at Harvard Medical School. Nick has made a name for himself as a clinical research and metabolic health educator, speaking and writing on topics ranging from brain health, the microbiome, mental health, muscle physiology, mitochondrial function, cholesterol and lipids, and so on.His mantra is “Stay Curious.”Amber O'Hearn Featured SpeakerAmber has been studying (and eating!) low carb diets of some form or other for the last 25 years, the last half of which has been almost entirely the Carnivore Diet, which she helped bring into modern awareness by giving the first conference talks on the diet in 2017, organising the first Carnivore conference in 2019, and writing the first scientific paper with "Carnivore Diet" in the title in 2020. As such, she has unique insight into the history of this trend and the common pitfalls of new adopters and influencers. Amber is a free speech maximalist and advocate of privacy-enhancing and censorship-resistant technologies.Bret Scher, MD Featured SpeakerDr. Scher is a board-certified cardiologist, lipidologist, and leading expert in metabolic and ketogenic therapies, and is the Director of Metabolic Mind, a non-profit initiative of Baszucki Group. Dr. Scher was the medical director at DietDoctor.com before becoming the director of Metabolic Mind. He also runs a preventive cardiology telemedicine practice at lowcarbcardiologist.com. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and prevent heart disease using low-carb nutrition and lifestyle interventions. Now Dr. Scher creates educational videos and podcasts regarding the connection between metabolic and mental health and how metabolic and ketogenic therapies can play a key role in mental health treatment. He believes we can revolutionize the mental health field through a greater understanding of metabolic therapies and therapeutic ketogenic interventions. You can find his content on The Metabolic Mind YouTube page and podcast and at www.metabolicmind.org.Darius Sharpe Featured SpeakerDarius has spent 23 years in emergency medicine. First as an EMT, then paramedic, and now as an ER nurse. Over that time he's watched astonishing improvements in emergency medical care while simultaneously seeing our population get fatter and sicker. This has led him down the path of nutritional science and to even take a closer look at his own health so that he can better educate his patients and the public.Adrian Soto-Mota, MD, PhD, FACP Featured SpeakerAdrian Soto-Mota obtained his MD in Mexico and specialized as an internist at Mexico’s National Institute of Medical Sciences and Nutrition. Afterwards, he trained as a Data scientist at Harvard and obtained my PhD in Physiology at Oxford. His research has focused on the clinical applications and prescription of dietary interventions. However, most of his collaborations involve advanced Statistical Analysis and Clinical Prediction Tools. He is an Internal Medicine consultant at Mexico’s National Institute of Medical Sciences and Nutrition, where he also lead the Metabolic Diseases Research Unit and Mexico’s Metabolic Biobank. Adrian is a Professor of Medicine at Tecnologico de Monterrey, where he teaches undergrad and grad students quantitative methods for biomedical research and Bioethics. He was recently recognized as a Fellow of the American College of Physicians in 2024 and received the Peter J Reeds Early Career Researcher Award from the American Society of Nutrition in 2025.Cynthia Thurlow Featured SpeakerCynthia Thurlow is a nurse practitioner, host of the Everyday Wellness podcast, author and international speaker, with over 15 million views for her second TEDx talk (Intermittent Fasting: Transformational Technique).With over 25 years experience in health and wellness, Cynthia is a globally recognized expert in perimenopause/menopause and intermittent fasting, and has been featured on ABC, FOX5, KTLA, CW, Medium, Entrepreneur, and The Megyn Kelly Show. Her mission is to help empower women to live their most optimal lives in perimenopause and beyond.Dr. Eric Westman Featured SpeakerDr. Eric Westman is an Associate Professor of Medicine at Duke University. He is Board Certified in Obesity Medicine and Internal Medicine, and founded the Duke Keto Medicine Clinic in 2006 after conducting clinical research regarding low carbohydrate ketogenic diets. He is Past-President and Master Fellow of the Obesity Medicine Association and Fellow of The Obesity Society. He is an editor of the textbook: Obesity: Evaluation & Treatment Essentials, and author of the New York Times Bestseller The New Atkins for a New You, Cholesterol Clarity, and Keto Clarity, and End Your Carb Confusion. He is co-founder of Adapt Your Life, an education company based on low carbohydrate concepts: https://adaptyourlifeacademy.com/Beth Zupec-Kania Citizen Science SpeakerBeth A. Zupec-Kania is a Registered Dietitian Nutritionist and the owner of Ketogenic Therapies LLC. She began her career as a hospital dietitian and, for over twenty years, specialized in managing ketogenic diets for epilepsy. After her hospital experience Beth established a private practice, providing ketogenic therapeutic guidance to individuals with neurological, endocrine, selected cancer, and psychiatric disorders. She also serves as a consultant in ketogenic research and has authored numerous educational resources for both consumers and professionals, including the “Ketogenic Diet Therapy for Neurological Disorders Pocket Guide.”Beth has trained doctors and dietitians at more than 300 medical centers and co-designed the Keto Mastery Therapeutics courses. She is the architect of KetoDietCalculator, a software tool for calculating and managing precision ketogenic therapies. As a founding member of Ketogenic Specialists, she also serves on the advisory boards of The Charlie Foundation, International Neurologic Ketogenic Society, Metabolic Mind, Glut1 Deficiency Foundation, Coalition for Metabolic Health, and AnorExit. Additionally, she is a member of the Academy of Nutrition and Dietetics and the Dietitians in Functional Medicine Practice GroupSponsorsBiocanicThe Charlie Foundation for Ketogenic TherapiesKeto Brainz NootropicsKeto BrickKeto-MojoKeto ChowMetabolic MindOwn Your LabsSALTTSwitchThe Society of Metabolic Health PractitionersWide Eye ProductionsRegister TodayRegistration Options* Iron ($25.00*) + Fees and ProcessingIncludes: In-Person Entry for all 3 days of the conference (*Tax Deductible Amount: $20) Bronze ($50.00*) + Fees and ProcessingIncludes: In-Person Entry for all 3 days of the conference, goodie bag filled with samples, coupons, and swag from our sponsors (*Tax Deductible Amount: $40) Silver ($100.00*) + Fees and ProcessingIncludes: In-Person Entry for all 3 days of the conference, goodie bag filled with samples, coupons, and swag from our sponsors, Commemorative CoSci 2026 Pin (*Tax Deductible Amount: $85) Gold ($250.00*) + Fees and ProcessingIncludes: In-Person Entry for all 3 days of the conference, goodie bag filled with samples, coupons, and swag from our sponsors, Commemorative CoSci 2026 Pin, Farewell Reception (Sunday) (*Tax Deductible Amount: $180) Emerald ($500.00*) + Fees and ProcessingIncludes: In-Person Entry for all 3 days of the conference, goodie bag filled with samples, coupons, and swag from our sponsors, Commemorative CoSci 2026 Pin, Farewell Reception (Sunday), VIP Dinner at Fogo de Chao (Friday) (*Tax Deductible Amount: $275) Diamond ($1,000.00*) + Fees and ProcessingIncludes: In-Person Entry for all 3 days of the conference, goodie bag filled with samples, coupons, and swag from our sponsors, Commemorative CoSci 2026 Pin, Farewell Reception (Sunday), VIP Dinner at Fogo de Chao (Friday), Exclusive Diamond Gift (*Tax Deductible Amount: $600) Non-Attendee Access To Presentation Recordings ($100.00*) + Fees and ProcessingCan't attend in person? 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