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Simons Foundation Autism Research Initiative | SFARIThe Simons Foundation Autism Research Initiative (SFARI) aims to improve the understanding, diagnosis and treatment of autism spectrum disorders by funding innovative research of the highest quality and relevance.Simons Foundation Autism Research Initiative | SFARI Simons Foundation chevron-down--small Program Areas Mathematics & Physical Sciences Life Sciences Autism Research Initiative Simons Collaborations Flatiron Institute Science, Society & Culture Multidisciplinary Programs Funding Funding Opportunities Independence Awards Policies and Procedures Award Instructions Simons Award Manager (SAM) FAQs and Videos News Announcements Articles Videos What We’re Reading Events Presidential Lectures Presents About About Us Media Relations Brand Portal Leadership Annual Report Diversity, Equity & Inclusion Careers Summer at Simons Contact Us COVID-19 Simons Foundation Autism Research Initiative (SFARI) SFARI’s mission is to improve the understanding, diagnosis and treatment of autism spectrum disorders by funding innovative research of the highest quality and relevance. SFARI chevron-down--small SFARI FundingFunding OpportunitiesSFARI Scientific PerspectivesFellows-to-FacultyGrant Policies and ProceduresSimons Award Manager (SAM) FAQ and Instructional VideosAcknowledgment PolicySign Up for RFA AnnouncementsResourcesAutism CohortsAutism Inpatient CollectionSimons SearchlightSimons Simplex CollectionSPARKModelsiPS cell modelsMouse modelsRat modelsZebrafish modelsOther ResourcesAutism BrainNetResearch MatchSFARI BaseSFARI GeneData analysis toolsTherapeuticsResearchSFARI InvestigatorsFunded ProjectsAutism Rat Models ConsortiumFunded CentersFunded PublicationsResearch HighlightsNewsSFARI NewsSFARI BlogSFARI ConversationsWorkshop and Meeting ReportsNewsletter ArchiveEventsAll EventsLecturesWebinarsSFARI SocialsEvent VideosAboutAbout UsDirector’s LetterContact UsCareer OpportunitiesOur TeamAdvisorsSFARI Scientific Advisory BoardSFARI Scientific Review BoardSPARK Scientific Advisory Board News Simons Foundation Announces 13 Recipients of 2024 Independence Awards The Simons Foundation is pleased to announce the latest recipients of its prestigious independence awards. The 13 talented early-career scientists will receive support as they transition from mentored training to independent research positions. Workshop and Meeting ReportsSFARI Gene Workshop Touches on the Future of Autism Gene Databases NewsAutism BrainNet: New Genetic Data Available News June 6, 2024 2023 Summer Pilot Awards Announced May 17, 2024 SFARI Sex Differences Collaboration Shares Findings at Second Annual Meeting March 26, 2024 Applications Open for 2024–2025 Undergraduate Research Fellowships in Neuroscience January 23, 2024 2023 SFARI Human Cognitive and Behavioral Science Awardees Announced View More Events Oct 07 iCalendar Google Calendar Yahoo Outlook October 7, 2024 6:30 - 8:30 p.m. EST SFARI Social Simons Foundation Autism and Neuroscience SfN Social Read More View All Events View Event Videos Subscribe to our newsletter and receive SFARI funding announcements and news Continue Available Resources Cohorts Autism Inpatient Collection Autism Inpatient Collection (AIC) is a study designed to produce a collection of phenotypic and genetic data from children with a clinical diagnosis of autism who have been admitted to one of six specialized inpatient… Simons Searchlight Simons Searchlight is studying individuals with recurrent genetic variants associated with autism and related neurodevelopmental disorders. Simons Simplex Collection The Simons Simplex Collection (SSC) contains genetic and phenotypic data from nearly 3,000 families with a child affected by autism. SPARK SPARK is an online research initiative that aims to recruit 50,000 individuals with autism and their family members living in the U.S. Models Mouse models SFARI is helping to make mouse models of high-risk autism genes and copy number variants available to the research community. Rat models SFARI is helping to make rat models of high-risk autism genes available to the research community. Zebrafish models SFARI is helping to make zebrafish models of high-risk autism genes available to the research community. Other Resources Autism BrainNet Autism BrainNet is a collaborative network of academic sites that collects, stores and distributes brain tissue for autism research. Data analysis tools A number of visualization and analysis tools are available to explore genetic and phenotypic data from the SSC, Simons Searchlight and SPARK. SFARI Base SFARI Base provides approved researchers with access to data and biospecimens from the SSC, Simons Searchlight, SPARK and Autism Inpatient Collection. SFARI Gene SFARI Gene is an evolving database for the autism research community that is centered on genes implicated in autism susceptibility. Therapeutics Clinical Research Associates (CRA) is evaluating new potential treatments for autism, including R-baclofen. Funding Opportunities We solicit applications for SFARI Awards from individuals who will conduct bold, imaginative, rigorous and relevant research in four main research areas: gene discovery, molecular mechanisms, circuits, cognition and behavior, and clinical. View Funding Opportunities Funded Research SFARI InvestigatorsProjectsPublications Since its launch in 2006, SFARI has supported over 550 investigators studying autism-related research in the U.S. and abroad. Research projects include studies at the genetic, molecular, cellular, circuit and behavioral levels, in addition to clinical and translational studies. Research Highlights Two studies using brain organoids reveal cell-type-specific changes during the early stages of human forebrain neuronal development in autismTwo studies by different research groups — one led by Flora Vaccarino and the other by Juergen Knoblich — used brain organoids derived from pluripotent stem cells of people with autism and showed how transcriptional alterations affecting certain cell types during human brain development could contribute to the early emergence of ASD. Excessive protein degradation is identified as a new cellular pathology and a potential target for therapeutic intervention in fragile X syndromeIn a mouse model of fragile X syndrome, Emily Osterweil and her colleagues show that excessive protein synthesis drives a pathological compensatory rise in protein degradation (by the ubiquitin proteasome system), which can be targeted to correct various phenotypes including audiogenic seizures. A novel eye-tracking paradigm identifies an influence of perceptual load on social attention in autismA study by Caroline Robertson and her colleagues found that reduced social attention was not a static omnipresent characteristic of autism; rather, it was magnified only under certain real-world conditions where sensory processing demands were high. View More Research Highlights Event Videos View all events → SFARI 2023 Human Cognitive and Behavioral Science RFA: Informational session March 7, 2023 On March 7, 2023, SFARI held an informational session about the 2022 Human Cognitive and Behavioral Science request for applications (RFA) Read More Share This SFARI 2023 Human Cognitive and Behavioral Science RFA: Informational session On March 7, 2023, SFARI held an informational session about the 2022 Human Cognitive and Behavioral Science request for applications (RFA) Read More SFARI 2022 Bridge to Independence Award RFA: Informational session January 10, 2022 SFARI hosted an informational session on the 2022 Bridge to Independence Award (BTI) request for applications (RFA). The session provided a brief overview of the BTI program... Read More Share This SFARI 2022 Bridge to Independence Award RFA: Informational session SFARI hosted an informational session on the 2022 Bridge to Independence Award (BTI) request for applications (RFA). The session provided a brief overview of the BTI program and its objectives from SFARI senior scientist Alice Luo Clayton and an open Q&A panel and breakout room discussions with current BTI fellows Gabriella Boulting, Marino Pagan, and Stephanie Rudolph. Read More Small molecules, genes and antisense oligonucleotides: Industry perspectives on treatment development for ASD May 14, 2021 Federico Bolognani, Stuart Cobb, and Yael Weiss joined a panel to discuss new industry developments on the use of small molecules, gene therapy and antisense oligonucleotides... Read More Share This Small molecules, genes and antisense oligonucleotides: Industry perspectives on treatment development for ASD Federico Bolognani, Stuart Cobb, and Yael Weiss joined a panel to discuss new industry developments on the use of small molecules, gene therapy and antisense oligonucleotides as treatment approaches for autism spectrum disorders (ASD). The panel discussion was moderated by Randall Carpenter. Read More New research results from the Australian Autism Biobank study May 12, 2021 Jake Gratten and Naomi Wray presented findings from the Australian Autism Biobank study, an initiative to establish an Australian resource of biospecimens, phenotypes and... Read More Share This New research results from the Australian Autism Biobank study Jake Gratten and Naomi Wray presented findings from the Australian Autism Biobank study, an initiative to establish an Australian resource of biospecimens, phenotypes and genomic data for autism research. Read More Other Initiatives SPARK is an online research initiative that aims to recruit 50,000 individuals with autism and their families. sparkforautism.org Spectrum is an editorially independent publication funded by SFARI spectrumnews.org Tweets by SFARIorg Subscribe to our newsletter and receive SFARI funding announcements and news Continue Simons Foundation SFARI’s mission is to improve the understanding, diagnosis and treatment of autism spectrum disorders by funding innovative research of the highest quality and relevance. Funding News Contact Us Resources Events Career Opportunities Research About © SFARI Privacy Policy Terms and Conditions Follow SFARI on Twitter Funding FundingFunding Opportunities SFARI Scientific Perspectives Fellows-to-Faculty Grant Policies and Procedures Simons Award Manager (SAM) FAQ and Instructional Videos Acknowledgment Policy Sign Up for RFA Announcements Resources ResourcesResourcesAutism Cohorts Autism CohortsAutism Inpatient Collection Simons Searchlight Simons Simplex Collection SPARK Models ModelsiPS cell models Mouse models Rat models Zebrafish models Other Resources Other ResourcesAutism BrainNet Research Match SFARI Base SFARI Gene Data analysis tools Therapeutics Research ResearchSFARI Investigators Funded Projects Autism Rat Models Consortium Funded Centers Funded Publications Research Highlights News NewsSFARI News SFARI Blog SFARI Conversations Workshop and Meeting Reports Newsletter Archive Events EventsAll Events Lectures Webinars SFARI Socials Event Videos About AboutAboutAbout Us Director’s Letter Contact Us Career Opportunities Our Team Advisors AdvisorsSFARI Scientific Advisory Board SFARI Scientific Review Board SPARK Scientific Advisory Board © SFARI Privacy Policy Terms and Conditions We care about your data, and we'd like to use cookies to give you a smooth browsing experience. 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